…looks like ivermectin worked well as a prophylactic and as a treatment after infection Compared to remdesivir it led to 70% less deaths in one large study from Miami In Brazil a very large peer reviewed study was done where a low dose given 2 days in a row every 15 days and it led to 44% reduction in infection rates 56% reduction in hospitalization 68% reduction in mortality glad we demonized that drug for no reason…
So, the big issue with COVID is the severity of symptoms varies so greatly that placebo effect and things like OTC meds are a real problem. Some infected people may not feel they have COVID, most people will recover on their own no matter what they do. Or what medicine they are given / take on their own. The standard way to evaluate a drug in these circumstances is a randomized, controlled trial. You randomly assign people to drug or not drug, dictate monitoring / reporting (people who don't are "lost to follow-up") and give the not drug group a placebo. Gold standard is also blinding the investigators so they can't subconsciously cheat in favor of their hypothesis. And RCTs are used in cancer and dementia, so severity of COVID is not a reason to not do them. An observational study Is normally reviewing records and reporting what happened. "Prospective observational," observing what happens going forward is usually used where the idea is something that cannot be ethically or practically placebo'd. Implants / surgery, psychotherapy, equipment, lifestyle. A rare condition (not possible to find enough willing people to randomize) or circumstances (e.g. astronauts on ISS) is also a reason. Using this design for an outpatient drug on often mild viral illness is very dubious and not an acceptable replacement for an RCT. Maybe learn more about these studies you’re posting?
Here’s a link to the study robbie, the fake news spreader and poor researcher, was referring to: https://www.cureus.com/articles/821...3128-subjects-using-propensity-score-matching That was chart review of a government policy. There was no pre-registration, no randomization, no blinding, no allocation concealment, no idea who did/did not take medicine/fill prescription. The groups who received/did not receive IVM were mismatched. The prescriptions were written based on physician "judgement". There was no follow up plan, no idea who saw doctors after the fact, who was lost to follow up. This will not be publishable in any journal that uses legitimate reviewers for methods/statistics and requires guidelines for study types. One of the author groups (FLCCC) has links to pharmacies and doctors selling the drug and consults online to get the drug. Quite the conflict of interest. There are now 20 meta-analyses, each that complied individual articles analyzing ivermectin use in COVID-19. After removing studies with fraud and impossible data, none show ivermectin prevents mortality. Meta-analyses do not establish improved mortality A link about Meta-analyses: https://journals.lww.com/americanth...s_Do_Not_Establish_Improved_Mortality.11.aspx
Literally an article from the CITY where the “study” was conducted in: “Therefore, considering, out of pure "thinking", that the number of deaths in the city would be directly related to a possible loosening of the measures recommended by the WHO because of prophylactic treatment with homeopathy, ivermectin or even ozone therapy (the latter which is only a national survey, with a reduced number of participants) does not match reality, since at no time was it recommended by the Department of Health to abandon the other measures recommended by specialists and health agencies: use of masks, social distancing, social isolation, hand hygiene, testing, among others. In addition, the Municipality maintains sanitary measures through constant decrees and inspections, in line with the Government of the State of Santa Catarina. It is important to clarify that the residents of Itajaí have always received guidance that the use of prophylactic treatments is not a cure for Covid-19, but a preventive action to be adopted periodically and in conjunction with other non-pharmacological measures. Just to illustrate, when the Department of Health began distributing ivermectin, 138,216 residents withdrew the first dose. Fifteen days later this number dropped to 93,970 people who took the second and third doses. Subsequently, only 8,312 people withdrew the fourth and fifth doses. That is, there was no fortnightly continuity of the use of ivermectin, as recommended. Itajaí is a beach town, which receives numerous tourists, like others from the state and Brazil where it is not simple to control the pandemic. However, it does not exempt itself from its responsibility, adopts several measures to combat Covid-19, has more than 2,000 professionals working on the front line to save lives, seeks preventive alternatives and follows all other recommendations from experts, as well as strictly complies with the protocols of the Ministry of Health and the State Department of Health in combating the pandemic and in testing for deaths. We regret the biased position seen in some reports, especially at this delicate time of pandemic. It is about exposing to the population a narrative based on assumptions, aiming only to criticize the use of prophylactic treatments, not analyzing the general context of the city and making suspicion to want to justify numbers, without any proof of this relationship.” https://saude.itajai.sc.gov.br/noti...imento--tratamentos-profilaticos#.YiXxemRMGA5
I don't think I've ever tried to spread "fake news". I might have made some poor/incorrect projections, but I've always tried to share accurate information. You might have me mixed up with someone else. Thank you for the link you found issuing a correction for the number of participants in the study. I haven't seen John Campbell get hoodwinked like that before so I didn't bother to look for actual refutation of the study before posting. There were 2 studies discussed in the video. https://www.sciencedirect.com/science/article/pii/S1201971221009887 That is a link to the first one from the U of Miami. Surprisingly, I can't find any greater depth to it than the summary. Again, that is disappointing to see and would seem to potentially undermine that as well. Thanks for helping with the correction.
So, I finally decide to ditch the mask when going to a few places. I take my car to the Dealer to get inspected and I go grocery shopping. Then, I proceed to get sicker than sh_t. Apparently, it isn't Covid as I took a home test twice a few days apart and tested negative. So, I assume it must be the flu. So, I've been reeling all f-ing week. I have had the worst sore throat I've ever had in my life to the point where I can't talk and it was hard to even swallow drink or food. The pain is unbelievable. My ears have been utterly clogged up all week so everything feels like I'm listening to stuff with five paper bags over my head. And, I just feel like total crap. It's not the worst flu I ever had but pretty close. The cold and flu medication helps a little but makes me feel strange as well. At one point, I was in a coughing fit so bad that I went from the bed to the floor knocking over all this stuff...and I don't even know how I got there on the floor. I blacked out from the coughing fit gasping for air and it happened at least twice. So much for ditching the mask and smooth sailing. At some point, the masks have to come off but why am I rewarded with this **** for when I do it? I only went the two f-ing places. F*ck!
In Japan they wear masks on public transit, always have, and don't cry and die from the flu like obese Americans. It's just a mask not a chastity cage for your penis. Wear one, don't wear one, whatever, but why yall be shaming people over it? Lulz.
Masks don’t protect you from getting sick. They protect others from you potentially spreading something to them. Assuming you aren’t wearing an N95 and regularly changing your filter.
They also have a fat law that penalizes companies for employing men with waists bigger than 33.5 inches. I'm all for public shaming and punishment of unhealthy practices.
Maybe coincidence but as soon we started relaxing on masks is when my family started getting sick. Didn't get sick through entire pandemic going to gym everyday and doing regular errands. Still doing same stuff but now just no mask. I guess it makes sense though since others aren't wearing them and that's what would've protected everyone. Also idiots at gym back to being disgusting and not washing hands and stuff. That was gross even before pandemic. Nonstop sick for almost two months now. Latest issue isn't anything I could've gotten from anyone though. So sick of being sick!
Ah well. Looks like China is the last country who is still trying to exert authoritarian rules over Covid. Once they capitulate, we will finally be free from Covid19
Welp, COVID finally hit us. Visited by the parents on Saturday, mom tested positive on Monday. Toddler woke up with a fever today and had a positive rapid test. Hopefully, the booster will prevent my wife and I from turning positive.
